What Happens When You Mix Ecstasy With Alcohol?

People often mix ecstasy/MDMA and alcohol because they think it enhances the effects on physical performance, but this is simply not true. Others combine them because it can make the euphoric effects of ecstasy last longer. However, once the neurotransmitters are depleted, and the euphoria wears off, it results in a “crash.” “Crashing” after an ecstasy and alcohol combination high can result in anxiety, trouble sleeping and depression.